Monday, May 21, 2012

The Dangers of Diabetic Drugs

Kaiser Permanente Insurance - The Dangers of Diabetic Drugs
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Diabetes Drugs associated with Heart Disease

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One base consider is either diabetes medications increase the risk of heart disease. The Food and Drug administration (Fda) requires oral diabetes medicines to carry a warning concerning increased risk of heart attack.

Several studies have associated a diabetes drug, Rosiglitazone, with cardiovascular mortality and morbidity. Rosiglitazone belongs to a class of anti-diabetic drugs knows as thiazolidinediones. The generic name of Rosiglitazone is Avandia. It is often referred to as an insulin sensitizer and used to treat habitancy suffering from type 2 diabetes.

Studies propose Avandia Poses a Higher Risk of Heart Ailments

According to two allembracing studies published in the Journal of the American healing Association, patients who consume Avandia face a higher risk of developing fatal heart ailments.

The study conducted by Dr. David Graham, the associate director of the Fda, examined the data collected from over 220,000 elderly diabetics in a Medicare condition guarnatee schedule who were either on Avandia or other diabetes treatment. The study found that patients on Avandia face an increased risk of stroke, heart failure and death, as compared to those not intriguing the drug.

The other study headed by Dr. Steven Nissen, chairman of cardiovascular treatment at the Cleveland Clinic in 2007 raised communal concern about the adverse cardiovascular outcomes of Avandia. The researchers performed a meta-analysis of the data collected from 56 different studies. They compared data from 35,000 patients on diabetes treatment. It was found that patients intriguing Avandia faced 33 percent more risk of having a heart charge as compared to patients on other treatments. Also, Avandia was associated with increased risk of myocardial infarction and death from cardiovascular ailments.

Some of the other side effects of Avandia are upper respiratory tract infection, back pain, headache, fatigue, sinusitis, hypoglycemia, diarrhea and edema.

Do Diabetes Drugs increase Risk of Cancer?

Conventional drug treatment for diabetes does not have a good track record. Prescribe drugs have discrete side effects and are associated with severe condition complications. Any researches have revealed that long-term use of some base diabetes drugs can increase the risk of cancer.

Oral Diabetes Medication May Raise Cancer Risk

An pathology of five-year data collected from an ongoing 10-year study, conducted by Takeda Pharmaceuticals, showed a link between the base anti-diabetes drug Actos and increased risk of bladder cancer. Actos is an oral Prescribe medication that is used for treating type 2 diabetes mellitus. The generic name of the drug is pioglitazone. It belongs to the class of drug called peroxisome proliferator-activated receptor (Ppar) agonists.

The observational cohort study was conducted on 193,000 diabetics associated with the Kaiser Permanente Northern California condition plan. The data was collected between January 1, 1997 and April 20, 2008. Higher incidents of bladder cancer were observed among patients who received pioglitazone for at least 2 years, as compared to those on other medication. Also, the diabetics with longest exposure to the drug and those with the top cumulative dose experienced higher risk of bladder cancer.

Another study, conducted by Larry L. Hillblom Islet research Centre at Ucla, associated a diabetes drug, sitagliptin with increased risk of pancreatic cancer and pancreatitis. Sitagliptin is used to treat type 2 diabetes. The study was conducted on 40 human Iapp transgenic (Hip) rats. Both sitagliptin and metformin were given to the rats for 12 weeks. The researchers found that some rats had exceptionally high rates of cell output in the pancreatic ducts. Few rats advanced a condition known as ductal metaplasia and pancreatitis.

A few other studies conducted on animals have associated Victoza, an additional one anti-diabetic drug, with increased risk of thyroid cancer.

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